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2021 Chevrolet Silverado
Diagnosis

2021 Chevrolet Silverado 5.3L Cylinder 5 Misfire Diagnosis

February 18, 2026
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Visitor Original question

I have a 2021 Chevy Silverado 5.3L with a consistent misfire on cylinder #5. I’ve already replaced the plug wires and the spark plug (the old plug was consistently fuel-soaked). I swapped the coil pack with cylinder #3 and the misfire stayed on #5. I also replaced injector #5. I can visibly see spark when testing the coil while it’s running, and compression on #5 while cranking is about 160 psi. Given these results, what are the most likely remaining causes and the next best diagnostic steps to isolate why cylinder #5 is still misfiring?

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Wizuto AI Response

You’ve covered the basics well: spark, plug, coil, injector, and compression all check out solid on cylinder #5. The fact that the misfire stays on #5 after swapping coils and replacing the injector points away from ignition and fuel delivery. Compression at 160 psi is decent, so mechanical failure like a bad valve or piston ring is less likely but not impossible.

Most likely causes now are timing-related sensor issues or valve problems that don’t show up in a static compression test.

Most likely culprits

  • Camshaft Position Sensor or Timing Signal Issue: If the cam sensor or its circuit is faulty, the ECM may mistime injector or ignition events on cylinder #5.
  • Valve Lash or Valve Damage: A valve that’s sticking or burnt can cause intermittent misfire even with decent compression.
  • Wiring or ECM Ignition Control Circuit: Less common but possible if the coil is getting spark but timing is off or intermittent.

How to narrow it down

  1. Scan for codes and live data: Check for camshaft position sensor codes or misfire codes with freeze frame data. Look at cam/crank correlation.
  2. Perform a running compression or cylinder leak-down test on #5: This can reveal valve sealing issues missed by static compression.
  3. Check camshaft position sensor wiring and connector: Look for corrosion, damage, or loose pins.
  4. Swap camshaft position sensor with a known good unit if possible: See if misfire moves or clears.
  5. Use a lab scope or scan tool to monitor ignition coil firing and injector pulse on #5: Confirm timing and duration match other cylinders.
  6. Inspect valve train on cylinder #5: If accessible, check rocker arms, lifters, and valve springs for damage or looseness.
  7. If all else fails, consider ECM or wiring harness faults: This is a last resort after mechanical and sensor checks.

Possible parts

  • Camshaft Position Sensor (only if scan data or wiring checks indicate fault)
  • Valve components (rocker arm, lifter) if valve train damage is found
  • Wiring harness repair or ECM replacement only if confirmed by diagnostics

A few questions

  • Are there any stored or pending trouble codes related to camshaft position or misfire?
  • Have you checked the wiring harness and connectors for cylinder #5 coil and injector for damage or corrosion?
  • Does the misfire occur under all conditions or only under load, idle, or certain RPM ranges?

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